Deep-learning based approach to identify substrates of human E3 ubiquitin ligases and deubiquitinases
John Wick E3 ubiquitin ligases (E3s) and deubiquitinating enzymes (DUBs) play key roles in protein degradation.However, a large number of E3 substrate interactions (ESIs) and DUB substrate interactions (DSIs) remain elusive.Here, we present DeepUSI, a deep learning-based framework to identify ESIs and DSIs using the rich information present in prot